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Projekte im Verbundkolleg Gesundheit

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Ozone and health

Exposure to ambient ozone, a currently under-investigated pollutant, is supposed to link to adverse health effects. Regarding this project, we plan to investigate associations between ambient ozone exposure and mental health, specifically concentrate on depressive symptoms. Based on our German birth cohorts and health care data, we can epidemiological analyze the association between ozone and depression. Furthermore, we could explore some possible underlying mechanisms that lie behind the associations, such as inflammation and dysfunctions of the endocrine system.

On the other hand, the project also attempts to illustrate the current general evidence on ambient ozone exposure and health outcomes. Therefore, we aim to perform an umbrella review on ambient ozone exposure and health effects by systematically reviewing existing systematic reviews. We will additionally supplement those ozone-effect pairs filtered from the umbrella review with original epidemiological and experimental evidence to provide a more comprehensive picture on ozone and health.

MITGLIED IM KOLLEG

seit

Betreuer Hochschule für angewandte Wissenschaften München:
Betreuer Ludwig-Maximilians-Universität München:

Prof. Dr. med. Dennis Nowak

3 bis 6 % des Bruttosozialprodukts gehen weltweit und auch in Europa durch gesundheitsschädliche Arbeitsplatzeinflüsse verloren. 16 % aller Todesfälle weltweitsind durch Umwelt-, insbesondere Luftverschmutzung bedingt. Die Differenz der mittleren Lebenserwartung zwischen der niedrigsten und höchsten Einkommensgruppe beträgt in Deutschland bei Frauen 8,4 Jahre und bei Männern 10,8 Jahre. Arbeits-, umwelt- und sozialmedizinische Themen, die wir wissenschaftlich beforschen, werden somit in den nächsten Jahren weiter eine unter Präventionsaspekten bedeutsame Rolle spielen.

 

Forschungsschwerpunkte:

  • Wirkung von Arbeits- und Umweltschadstoffen auf die menschliche Gesundheit
  • Psychische Gesundheit am Arbeitsplatz
  • Klimawandel: Beiträge zur Prävention, Beiträge zur Anpassung

Betreute Projekte:

Publikationen

Bao X., Shi R., Zhao T., Wang Y., Anastasov N., Rosemann M. und W. Fang (2021):

Integrated analysis of single-cell RNA-seq and bulk RNA-seq unravels tumour heterogeneity plus M2-like tumour-associated macrophage infiltration and aggressiveness in TNBC. In: Cancer Immunology, Immunotherapy, 70(1), S. 189-202. doi.org/10.1007/s00262-020-02669-7.

Bao*, X., Shi*, R., Zhao, T., und Y. Wang (2020):
Mast cell-based molecular subtypes and signature associated with clinical outcome in early-stage lung adenocarcinoma. Molecular oncology. https://doi.org/10.1002/1878-0261.12670.

Bao*, X., Shi*,R., Zhao, T. und Y. Wang (2020):
Immune landscape and a novel immunotherapy-related gene signature associated with clinical outcome in early stage-lung adenocarcinoma. Journal of Molecular Medicine. https://doi.org/10.1007/s00109-020-01908-9.

Luo Y.-N., Huang W.-Z., Liu X.-X., Markevych I., Bloom M.S., Zhao T., et al. (2020):
Greenspace with Overweight and Obesity: A Systematic Review of Epidemiological Studies Up to 2020. In: Obesity Review, 21(11). https://doi.org/10.1111/obr.13078

Sun J., Zhao T., Zhao D., Bao X., Shi D., Su C. (2020):

Development and validation of a hypoxia-related gene signature to predict overall survival in early-stage lung adenocarcinoma patients. In: Therapeutic Advances in Medical Oncology. doi.org/10.1177/1758835920937904

Weisenberg, H., Zhao, T., und J. Heinrich (2020):
Combinations of Epidemiological and Experimental Studies in Air Pollution Research: A Narrative Review. International Journal of Environmental Research and Public Health. https://doi.org/10.3390/ijerph17020385.

Yang*, B.-Y., Shi*, T.-X., Luo, Y.-N., Liu, X.-X., Zhao, T., Bloom, M. S., et al. (2020):
Ambient air pollution and homocysteine: Current epidemiological evidence and a call for further research. Environmental Research. https://doi.org/10.1016/j.envres.2020.109679.

Zhao T., Markevych I., Janßen C., NowakD., Steckling-Muschack N. und J. Heinrich (2020):

Ozone exposure and health effects: a protocol for an umbrella review and effect-specific systematic maps. BMJ Open. dx.doi.org/10.1136/bmjopen-2019-034854

Zhao, T., Tesch, F., Markevych, I., Baumbach, C., Janßen, Ch., et al. (2020):
Depression and anxiety with exposure to ozone and particulate matter: an epidemiological claims data analysis. International Journal of Hygiene and Environmental Health. https://doi.org/10.1016/j.ijheh.2020.113562.

Zhao, T., Markevych, I., Standl, M., Schulte-Koerne, G., Schikowski, T., Berdel, D. et al. (2019):
Ambient ozone exposure and depressive symptoms in adolescents: Results of the GINIplus and LISA birth cohorts. Environmental Research. 170, 73-81. https://doi.org/10.1016/j.envres.2018.12.014.

Yang, B-Y., Guo, Y., Bloom, M.S., Xiao, X., Qian, Z., Liu, E., Howard, S. W., Zhao, T. et al. (2019):
Ambient PM1 air pollution, blood pressure, and hypertension: Insights from the 33 Communities Chinese Health Study. Environmental Research. 170, 252-259. https://doi.org/10.1016/j.envres.2018.12.047.

Zhao, T., Markevych, I., Standl, M., Schikowski, T., Berdel, D., et al. (2019):
Short-term exposure to ambient ozone and inflammatory biomarkers in cross-sectional studies of children and adolescents: Results of the GINIplus and LISA birth cohorts. Short-term exposure to ambient ozone and inflammatory biomarkers in cross-sectional studies of children and adolescents: Results of the GINIplus and LISA birth cohorts. Environmental Pollution 2019; 255:113264. https://doi.org/10.1016/j.envpol.2019.113264.

Fan, S.-J., Heinrich, J., Bloom, M. S., Zhao, T.-Y., Shi, T-X., Feng, W.-R., et al. (2019):
Ambient air pollution and depression: A systematic review with meta-analysis up to 2019. Science of the total environment. 701,https://doi.org/10.1016/j.scitotenv.2019.134721.

Zhao, Markevych, I., Romanos, M., Nowak, D. und J. Heinrich (2018):

Ambient ozone exposure and mental health: A systematic review of epidemiological studies. Environmental Research. 165, 459-472. doi.org/10.1016/j.envres.2018.04.015.

 

 

Präsentationen und Poster

Zhao, T. (2020):
ERS 2020, 30th European Respiratory Society International Congress, 07.09 – 09.09.2020, Wien, Österreich 30th (virtual).

Zhao, T. (2020):
Poster report: Ozone and COPD: a systematic map of epidemiological and experimental studies.

Zhao, T. (2019):
ICUH 2019, 16th international conference on urban health.

Zhao, T. (2019):
ISEE, 31st annual conference of the International Society for Environmental Epidemiology.

Zhao, T. (2018):
ISEE Young, 3rd Early Career Researchers Conference on Environmental Epidemiology.

Tianyu Zhao

Tianyu Zhao

Ludwig-Maximilians-Universität München

Koordination

Treten Sie mit uns in Kontakt. Wir freuen uns auf Ihre Fragen und Anregungen zum Verbundkolleg Gesundheit.

Dr. Sabine Fütterer-Akili

Dr. Sabine Fütterer-Akili

Koordinatorin BayWISS-Verbundkolleg Gesundheit und BayWISS-Verbundkolleg Ökonomie

Universität Regensburg
Zentrum zur Förderung des wissenschaftlichen Nachwuchses
Universitätsstraße 31
93053 Regensburg

Telefon: +49 941 9435548
gesundheit.vk@baywiss.de